Appendix Ii Protocols And Reporting Forms For Testing Chemicals Through Pam I Multiresidue Methods
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5236F2BEE4164BAC83957C7885904499 |
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文件大小(MB)： |
0.1 |
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页数： |
34 |
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日期： |
2002-6-11 |
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文本摘录（文本识别可能有误，但文件阅览显示及打印正常，pdf文件可进行文字搜索定位）：
Pesticide Analytical Manual Vol. I APPENDIX II,Transmittal No. 94-1 (1/94),Form FDA 2905a (6/92) Appendix II–1,APPENDIX II: PROTOCOLS AND REPORTING,FORMS FOR TESTING CHEMICALS THROUGH,PAM I MULTIRESIDUE METHODS,INTRODUCTION: MULTIRESIDUE METHOD TESTING,Use of any multiresidue method (MRM) is supported by available information,about how potential residues behave through the steps of the method. To provide,that support for PAM I MRMs, additional chemicals are continually tested through,the method steps and the resulting data compiled in a single database. All PAM,I tables in Chapters 3 and 4 and Appendix I are produced from that database.,This Appendix provides directions for performing such tests and forms for reporting,results.,The effort spent on the testing of MRMs and compilation of results is justified by,the advantages such compilations offer the analytical chemist. When analytical,behavior data for numerous chemicals through the method in use are known, the,analyst is better equipped to identify residues that may be present in a sample of,unknown treatment history. In situations where the likelihood of some particular,residue is known, the data lists for several methods can be consulted to help,choose which method should be used.,Regulatory agencies often must assess the incidence of residue occurrence. This,effort is also assisted by compilations of method behavior data. The absence of,many chemicals from the sample can be ascertained when it is known that those,chemicals could have been detected had they been present.,It has been found advisable to define protocols for developing data on MRM,behavior. In order to compile data into usable formats, it is imperative that all,contributing laboratories perform the tests uniformly. The goal of this methodtesting,is not to find the optimum conditions for the one chemical currently being,tested, but to be able to describe how the chemical will behave when determined,by the precisely defined method.,This Appendix includes one protocol for determining GLC characteristics of chemicals,and six protocols for testing their behavior through individual MRMs. Forms,for reporting the results of testing by each protocol are also included. Each protocol,references the PAM I method(s) involved, the types of chemicals to which,it applies, and the PAM I table(s) in which previously collected data are published.,Some PAM I MRMs are applicable to a wide variety of residues, while others are,targeted to those with specific chemical structures. A Decision Tree is included in,this Appendix to direct the user to the most appropriate protocol(s) for each,chemical being tested. Follow the Decision Tree in deciding which protocol(s) to,use.,Follow the steps of these protocols, in the order written. Report data on a copy of,Administration, 200 C Street SW, Washington, DC 20204.,Transmittal No. 94-1 (1/94),Appendix II–2 Form FDA 2905a (6/92),APPENDIX II Pesticide Analytical Manual Vol. I,Decision Tree for MRM Testing,Do data already exist (Index to Methods, Appendix I)?,Develop only data not,yet available.,Yes,No,Does the compound have this structure or characteristic:,Yes,Yes,Yes,Yes,Determine GLC characteristics per Protocol C, Level I.,Does it chromatograph on GLC systems?,No,Discontinue tests.,No,Yes,Does it chromatograph on at least one Level I,system in a reasonable time (0.3
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